Appication of Fluorecent Triazoles to Analytical Chemistry. II. : Fluorescent Derivatization of Carboxylic Acids
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概要
- 論文の詳細を見る
2-(p-Aminomethylphenyl)-N, N-dimethyl-2H-benzotriazolyl-5-amine (1) and two related compounds (2 and 3) were synthesized as highly sensitive fluorescence derivatization reagents for carboxylic acids. These reagents reacted with carboxylic acids activated with 2-bromo-1-ethylpyridinium tetrafluoroborate to produce the corresponding fluorescent amides at room temperature. We investigated the fluorescence characteristics and the chromatographic behavior of the benzamide derivatives of the reagents. Compound 1 was selected for use in high-performance liquid chromatography (HPLC). A highly sensitive and convenient fluorescence HPLC method was developed for the determination of carboxylic acids. The detection limit for carboxylic acids was 15 fmol per injection.
- 公益社団法人日本薬学会の論文
- 1989-03-25
著者
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成田 滋
Shionogi Research Laboratories Shionogi & Co. Ltd.
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北川 隆康
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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北川 隆康
塩野義製薬(株)研究所
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