Application of Fluorescent Triazoles to Analytical Chemistry. I. Determination of Aromatic Primary Amine with 2,4,6-Triaminopyrimidine as a Reagent
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概要
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A sensitive fluorometric method for the determination of primary aromatic amines was developed. The procedure requires diazotization of the amino group followed by coupling with 2,4,6-triaminopyrimidine (TAP), and the resulting azo compound is oxidized to a fluorescent triazole. Substituted triazoles were synthesized by using various pyrimidines and their fluorescence characteristics were evaluated. TAP was selected as the most sensitive reagent. None of the pyrimidines substituted at the 2-position was fluorescent. A method for the determination of sulfamethoxazole (SMX) was established (quantitation limit : 40 ng/ml). This method is more practical and simple than that reported before : the final solution for measurement was obtained in one flask through a one-pot reaction. The effects of substituents of the triazole ring on the fluorescence are discussed.
- 公益社団法人日本薬学会の論文
- 1985-11-25
著者
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成田 滋
Shionogi Research Laboratories Shionogi & Co. Ltd.
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北川 隆康
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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北川 隆康
塩野義製薬(株)研究所
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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