The Behavior of 4-Amino-5-carboxy-2-methylpyrimidine in Aqueous Solution
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概要
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The behavior of 4-amino-5-carboxy-2-methylpyrimidine (ACMP) was compared with those of 2-aminoisonicotinic acid (ANA) and 2-aminoisonicotinic acid (AINA) in water. The behaviors of these compounds were investigated spectrophotometrically by comparison with those of the corresponding ethyl ester and 1-methyl betaine. The Edsall-Blanchard equation was used to evaluate the equilibrium constants, K_z between zwitterion from and uncharged from in water. The evaluated K_z values indicated that ACMP, ANA and AINA existed almost completely in the zwitterion form in water, respectively. This result was in good agreement with the spectrophoto-chemical observations.
- 公益社団法人日本薬学会の論文
- 1966-08-25
著者
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratories Shionogi And Co. Ltd.
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