Analytical Studies on Isoxazoles. I. A New Colorimetric Determination of 5-Substituted 3-Isoxazolecarboxylic Acids and Their Derivatives
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概要
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A new colorimetric method for the determination of 5-methyl-3-isoxazolecarboxylic acid (MIA) and 5-phenyl-3-isoxazolecarboxylic acid (PIA) was established. This method is based on the decomposition of 5-substituted 3-isoxazolecarboxylic acids to the corresponding β-ketonitriles, followed by condensation with p-dimethylaminobenzaldehyde (DABA). The 5-carboxylic isomers caused no interference in the determination of MIA and PIA. Further applications of this method to perisoxal (II), N-[(dimethylamino) carbonyl]-5-methyl-3-isoxazolecarboxamide (III), and 3-(2-oxazolin-2-yl)-5-methylisoxazole (IV), by decomposition to the corresponding 5-substituted 3-isoxazolecarboxylic acids, followed by the color reaction with DABA, are described.
- 公益社団法人日本薬学会の論文
- 1980-04-25
著者
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梅田 常二
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratories Shionogi And Co. Ltd.
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今西 裕子
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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今西 裕子
Shionogi Research Laboratory Shionogi And Co. Ltd.
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