CONTINUOUS MONITORING OF UNBOUND FLOMOXEF LEVELS IN RAT BLOOD USING MICRODIALYSIS AND ITS NEW PHARMACOKINETIC ANALYSIS
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概要
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Microdialysis sampling method coupled to high-performance liquid chromatography with UV detection was applied to continuous monitoring of in vivo unbound flomoxef concentration in rat blood. By comparison with ultrafiltration method, it was demonstrated that it gave reliable results for the unbound drug monitoring in blood. Furthermore, a new method was presented for the calculation of pharmacokinetic parameters from the data obtained by the microdialysis method.
- 社団法人日本薬学会の論文
- 1991-03-25
著者
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税所 優
Shionogi Research Laboratories Shionogi & Co. Ltd.
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梅田 常二
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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梅田 常二
Shionogi Research Laboratories Shionogi & Co. Ltd.
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- CONTINUOUS MONITORING OF UNBOUND FLOMOXEF LEVELS IN RAT BLOOD USING MICRODIALYSIS AND ITS NEW PHARMACOKINETIC ANALYSIS
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