イソキサゾール類に関する分析化学的研究(第3報)イソウロンの比色定量
スポンサーリンク
概要
- 論文の詳細を見る
Isouron (1), one of the urea herbicides was determined colorimetrically by application to diazo coupling with Tsuda reagent. 3-Amino-5-tert-butylisoxazole (2) obtainable by the hydrolysis of 1 was diazotized with HNO_2 and the diazonium salt was easily coupled with Tsuda reagent. The diazonium salt was unstable at room temperature different from aniline but stable in cooled water. The calibration curve was linear in a range of 3-15 μg/ml of the standard solution of 1,the coefficient of variation of 0.3-1.3%. 5-Amino-3-tert-butylisoxazole (6) produced by the hydrolysis of the isomer 1-(3-tert-butylisoxazol-5-yl)-3,3-dimethylurea (5) was not diazotized in the present condition. The effect of major impurity (5) on the determination was removable.
- 公益社団法人日本薬学会の論文
- 1981-06-25
著者
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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北川 隆康
塩野義製薬(株)研究所
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平井 瑛三
塩野義製薬株式会社研究所
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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岩倉 久美子
Shionogi Research Laboratories Shionogi And Co. Ltd.
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岩倉 久美子
塩野義製薬株式会社研究所
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