Analytical Studies on Isoxazoles. V. Colorimetric Determination of Isouron and Its Isomer with p-Dimethylaminocinnamaldehyde

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概要

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• Isouron (1) and its isomer, 1-(3-tert-butylisoxazol-5-yl)-3,3-dimethylurea (2), were determined by a colorimetric method with p-dimethylaminocinnamaldehyde (DACA) as the reagent. Compounds 1 and 2 were hydrolyzed to give 3-amino-5-tert-butylisoxazole (3) and 5-amino-3-tert-butylisoxazole (4), respectively, which were transformed into colored substances by reaction with DACA. The former colored product was a Schiff base but the latter product had a different absorption maximum from the corresponding Schiff base. The latter color reaction resulted in a bathochromic shift as compared with Schiff base formation at the 5-position. Traces of 2 (more than 0.05%) in 1 could be estimated precisely together with the quantitation of 1 by making use of this bathochromic effect.

• 公益社団法人日本薬学会の論文
• 1984-07-25

著者

• 北川 隆康

  Shionogi Research Laboratories, Shionogi & Co., Ltd.,

• 北川 隆康

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 平井 瑛三

  Shionogi Research Laboratory, Shionogi and Co., Ltd.

• 北川 隆康

  塩野義製薬(株)研究所

• 大杉 昌子

  Shionogi Research Laboratories, Shionogi and Co., Ltd.

• 岩倉 久美子

  Shionogi Research Laboratories, Shionogi and Co., Ltd.

• 大杉 昌子

  Shionogi Research Laboratories Shionogi And Co. Ltd.

• 平井 瑛三

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 岩倉 久美子

  Shionogi Research Laboratories Shionogi And Co. Ltd.

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