Colorimetric Determination of 4-Chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycylglycinanilide with 3,5-Dibromosalicylaldehyde. II. Reaction Mechanism of Coloration
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概要
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In connection with our studies to develop an assay method for 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycylglycinanilide (1), a colored substance formed by the reaction of 1 with the reagent 3,5-dibromosalicylaldehyde (DBSA) was isolated and its chemical structure was investigated. Another colored substance formed by the same reaction of glycinemonomethylamide (3) with DBSA was also isolated, and the chromophoric structure was shown to be essentially the same as that of the compound formed in the reaction of 1 with DBSA. On the basis of spectrometric and chemical evidence, the colored compounds were determined to be N-substituted 5-(3,5-dibromo-2-hydroxybenzylidene)-2-(3,5-dibromo-2-hydroxyphenyl)-1-imidazoline-4-ones. The reaction mechanism of the coloration in the assay of 1 is discussed.
- 公益社団法人日本薬学会の論文
- 1984-02-25
著者
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北川 隆康
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平井 瑛三
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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北川 隆康
塩野義製薬(株)研究所
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池西 利喜夫
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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池西 利喜夫
Shionogi Research Laboratories Shionogi & Co. Ltd.
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