Ion Pair Extraction of Trimethoprim with Sulfonphthalein Dyes
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概要
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Ion pair extraction of a basic drug (trimethoprim) with sulfonphthaleins (BTB, BCG and BPB) was examined on the basis of equation (1). [numerical formula] The molar ratio, Q, of the extracted ion pair (Q=[BH^+IH^-]_<org>/(C_B-[BH^+IH^-]_<org>)) was represented as a function of the hydrogen ion activity ((α_H)_W) and the concentration of the sulfonphthalein monoanion ([IH^-]_W). The extraction constant, K_<ex>, of the equilibrium (2) was estimated from equation (1). [numerical formula] The log K_<ex> values of TMP-BTB were found to be 5.26,7.08 and 8.10 in benzene-H_2O, 1,2-dichloroethane-H_2O and CHCl_3-H_2O systems, respectively. The log K_<ex> values of TMP-BCG and TMP-BPB in the 1,2-dichloroethane-H_2O system were found to be 5.89 and 4.95,respectively. The effect of pH on the ion pair extraction is discussed in terms of equation (1). The pH values suitable for the assay of TMP with BTB by means of ion pair extraction were found to be in the range of 4 to 6.
- 公益社団法人日本薬学会の論文
- 1980-03-25
著者
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北川 隆康
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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北川 隆康
Shionogi Research Laboratories Shionogi & Co. Ltd.
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足立 葉子
Shionogi Research Laboratory Shionogi And Co. Ltd.
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平井 瑛三
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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北川 隆康
塩野義製薬(株)研究所
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平井 瑛三
Shionogi Research Laboratories Shionogi & Co. Ltd.
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