生薬主成分の分析化学的研究(第6報)センブリ含有製剤中のスウェルチアマリンの定量とその安定性

概要

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A simple and rapid high-performance liquid chromatographic (HPLC) procedure was established for the quantitative determination of swertiamarin in compound of pharmaceutical preparations including swert. Herb. Pulv. Swertiamarin was extracted with water from pharmaceutical pharmaceutical preparations, cleaned up through SEP-PAK C_<18>^[○!R] cartridge and analyzed by HPLC. Swertiamarin was separated with a mobile phase of H_2O-CH_3CN (9 : 1) mixed solution on Nucleosil _<10>C_<18> column. Stability of swertiamarin in pharmaceutical preparations was also investigated. It was concluded that the combination of Swert. Herb. Pulv. with antacids accelerated the decomposition of swertiamarin, and that with crude drugs and digestive enzymes did not give any significant influence. The decomposition behavior of swertiamarin in aqueous solution was studied to be pseudo first order reaction.
1982-03-25