Studies on Powdered Preparations. XIV. Wetting of Powder Bed and Disintegration Time of Tablet

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1. The penetrating rate constants of water and ethanol into magnesium oxide and AS powder beds were obtained with a satisfactory reproducibility. These results were in accord with Washburn's equation. 2. The penetrating rate constants in these systems were dependent on the temperature of liquid according to log k/T=α-β/RT and apparent activation energies of wetting were obtained as a few kcal. 3. Dependence of the penetrating rate constant on moisture content of powder was remarkable in systems of relatively small k values like AS/water and magnesium oxide/ethanol. 4. The apparent activation energy of wetting was concerned with the moisture content of powder. 5. The disintegration time of tablet was dependent on the temperature of liquid as well as on the compressional force. The temperature dependence of disintegration time was almost the same as that of penetrating rate constant. 6. The immersional wetting might be a controlling factor on the disintefration of the tablet made under a low compressional force.
公益社団法人日本薬学会の論文
1966-02-25