Application of Interpolymer Complexation of Polyvinylpyrrolidone/Carboxyvinyl Polymer to Control of Drug Release(Pharmaceutical,Chemical)

概要

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Interpolymer complex formation of polyvinylpyrrolidone (PVP) with carboxyvinyl polymer (CP) was examined by turbidity measurement, a binding isotherm study and Fourier-transform infrared spectroscopy. The interpolymer complex of PVP with CP was found to be formed in the unit molecular ratio of 1:1 under ideal conditions, though the ratio of PVP in the solid complex was lower than 1:1 under practical conditions. Hydrogen bonding might be the driving force for the complexation, and the degree of hydrogen bonding was calculated to be about 40 to 50%. The slowest dissolution rate of chlorpheniramine maleate from tablets, which consisted of a blend of PVP and CP was observed when the polymer combination ratio was 1:1. In the case of indomethacin, the longest lag time for the dissolution was observed at the polymer ratio of 1:1. Therefore, the drug dissolution behavior from PVP/CP tablets is dependent on the complex formation of PVP and CP.
1987-12-25