Pharmacokinetic Studies of Biliary Excretion. I. Comparison of the Excretion Behavior in Azo Dyes and Indigo Carmine

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The kinetic investigation about the factors affecting the biliary excretion was tried with azo and indigoid dye in rat. Five azo dyes, i.e., Azorubin S, Amaranth, New Coccine, Ponceau R, Ponceau SX, and Indigo Carmine as indigoid dye were used. (1) All dyes except New Coccine used here began to be excreted within 2-5 min and the peak of the excretion rate appeared between 10 and 20 min after administration. But as for New Coccine which had the very low excretion ratio, the delay of the excretion was observed and the peak of the excretion rate was hardly observed. (2) The dose dependency of biliary excretion which had been found in riboflavin was also found in dyes, and accordingly, the dependency was considered not to be specific to a biological substance such as riboflavin. (3) In the excretion rate constant, all dyes which showed high dose type excretion pattern had two rate constants k_1 and k_2 as shown in riboflavin, and the ratios of them were between 1.4 and 3. (4) It was also found that not only the number of sulfonate groups, but also the position of them had an effect on the biliary excretion ratio. (5) The biliary excretion pattern of Indigo Carmine which is likely to be excreted in urine was not different essentially from those of azo dyes of which the ratio was high.
社団法人日本薬学会の論文
1970-12-25