調剤環境の空気清浄度に関する定量的解析 : 無塵化調剤室の導入と評価

概要

論文の詳細を見る
A dust-free dispensing facility (total area of 320m^2,consisting of eight dispensing rooms) with Class M5.5 cleanness was designed, along with the construction of a new clinic ward for outpatients in the University of Tokyo Hospital in 1994. Air cleanness inside the rooms was measured by counting air-floating microparticles in an optical particle-size analyzer. Air cleanness in the absence of pharmacists in the conventional dispensing rooms was very low at levels worse than Class M6.5,while that in the dust-free dispensing rooms was high at around Class M3.5. In the tablet-counting room, the air particle concentration increased with the entry and working of pharmacists, then varied in the range of Class M4.5-M5.3 depending on the number of residing pharmacists and extent of their movement, and decreased to the original condition after the exit of pharmacists after work. Moreover, in the powder-dispensing room, air cleanness around mixing tables and automatic powder packaging machines varied widely from Class M4.5 to M5.5. Not only large-sized microparticles but small ones (0.5-1.0μm) were detected through the processes of weighing, mixing, and packaging the powder, probably due to redistribution of microparticles gathered in a vacuum cleaner attached to the powder packaging machine. It was thus proposed to use HEPA filters with a pore size <0.5μm in the cleaner for gaining a clearer environment of dispensing. In conclusion, it was suggested that the introduction of a dust-free dispensing facility is feasible not only for providing patients with highly qualified medications but also for the assurance of pharmacists' safety by avoiding exposure to the drug powder, when working with unit-dose packaging of tablets and capsules as well as decapsulization and tablet crashing of highly bioactive agents.
社団法人日本薬学会の論文
1999-06-01

調剤環境の空気清浄度に関する定量的解析 : 無塵化調剤室の導入と評価

スポンサーリンク

概要

著者

関連論文

スポンサーリンク