インドメサシンの生物薬剤学的研究(第2報) : ラット小腸管吸収機構およびヒト経口投与時における微粉化製剤の利用率

概要

論文の詳細を見る
The intestinal absorption of Indomethacin in a rat was examined in vitro in relation to its pKa and solubility. The availability of Indomethacin capsule (micronized powder) was calculated from the total amount excreted after oral administration to healthy men. 1) Indomethacin was strongly bound to the intestinal tissue in the process of absorption and the binding was dependent on pH. 2) The ionized form of Indomethacin was absorbed as was the nonionized form. 3) The dose dependency of absorption reported in the preceding paper was explained by the binding ratio of Indomethacin to the intestinal tissue. 4) The availability of micronized Indomethacin was high in man (96.2%) as in a rabbit.
社団法人日本薬学会の論文
1971-11-25