ニューキノロン剤吸収に対する金属カチオン含有の制酸剤・消化性潰瘍用剤による時間依存的阻害と服薬のための設計

概要

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The bioavailability of orally administered new quinolones is markedly decreased in the presence of magnesium-aluminum antacids, calcium carbonate, sucralfate or ferrous salts. With respect to the effect of antacids, the absorption of all new quinolones appears to be significantly reduced by antacids containing magnesium and/or aluminum, and so concomitant administration must be avoided. Other cations, such as calcium, iron and probably zinc appear to interact in a similar manner. Chelation between the new quinolones and metal cation is the most likely mechanism. In this review, we propose methodology for avoidance of drug interaction with metal cations and recommend some drugs as alternatives to antacids and anti-ulcer drugs for patients treated with new quinolones.
日本医療薬学会の論文
1992-02-20