プロピオン酸フルチカゾンドライパウダーインヘラー使用後の口腔内付着薬物の除去に及ぼす含嗽の効果

概要

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The effect of mouth wash on the removal of drug residues in both mouth and pharynx after the use fluticasone propionate dry powder inhaler(FP-DPI) was studied. The concentration of FP in mouth wash after sprinkle and inhalation of Flutide^[○!R] 50, 100, 200 Rotadisk^[○!R] was determined by HPLC-UV. The total amount of the removed FP was measured by the sum of the concentration of FP in 5 times of mouth washes. The mouth wash procedures removed totally 79.3±4.4%(50μg), 68.5±3.6%(100μg), 69.3±3.4%(200μg)of sprinkled amount of FP and 29.5±11.1%(50μg), 35.6±6.6%(100μg), 31.6±8.3%(200μg)of inhaled, respectively. It was required for the removal of 90% of the totally recovered FP to do two times of mouth washes in each case. These data suggest that the mouth wash is an effective precaution for candidiasis induced by FP delivered by DPI.
社団法人日本薬学会の論文
2001-03-01