The Relationship between the Pharmacological Effect of Amitriptyline Based on an Improved Forced-Swimming Test and Plasma Concentration in Rats

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概要

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• The relationship between the plasma concentration of amitriptyline (AMI) and its pharmacological effect was investigated in rats. The plasma concentration of AMI was maintained constantly from 5 h to 7 d after intraperitoneal infusion by the implantation of an osmotic minipump with an adjusted release rate of 20 mg/kg/d of AMI. Neither the plasma or brain concentrations of AMI in a 24-h infusion group were significantly different as compared with those in the 7-d group. The pharmacological effect of AMI was measured by our improved forced-swimming test. When AMI (dose of 20 and 50 mg/kg/d) was infused, the pharmacological effect in both infusion groups of rats was increased significantly at each dose in comparison to that of the control rats (p<0.05). With 10 mg/kg/d infusion, the effect in the 7-d group increased significantly as compared with that of the control (p<0.05), although the effect in the 24-h group did not change. The effect was increased in both groups with an increase of dose. When the effect was plotted to the area under the plasma concentration-time curve (AUC), the effect approached a limiting value (12 μg/ml・h). Therefore, it was suggested that 12 μg/ml・h as the AUC for AMI was enough to obtain a maximum AMI pharmacological effect in rats. From these results, we concluded that the AUC for AMI may be a useful index to evaluate its pharmacological effect, rather than the plasma concentration.

• 公益社団法人日本薬学会の論文
• 1995-01-15

著者

• 伊賀 立二

  Departments of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of To

• 伊賀 立二

  Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine University Of Tokyo

• 大島 夏生

  Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo

• 小滝 一

  Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tok

• 澤田 康文

  Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tok

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