Studies on Tablet Disintegration. I. The Effect of Penetrating Rate on Tablet Disintegration.
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概要
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The effects of the penetrating rate on tablet disintegration were examined. Viscosity, surface tension, contact angle of liquid and the mean capillary diameter of tablet were measured and their effects on disintegration were discussed. In high viscosity solution, the rate of penetration decreased and the disintegration was not well. The viscosity of gastric juice was measured and tablet disintegration in human gastro-intestinal tract was examined by X ray. It was estimated that a tablet disintegration might be affected by the viscosity of gastric juice. The rate of penetration of powder in a surfactant solutions and the penetration of the powder coated by surfactant in pure water were measured. The effect of surfactant on disintegration could not be generally expected due to the decrease of surface tension. The mean diameter of open capillary in a tablet was measured by air permeametry. The diameter was decreased by a large compressional force in tableting and increased by a large quantity of disintegrator. The equation of penetrating rate was discussed theoretically to apply it for the penetrating in tablet capillary. It was concluded that Washburn's equation of penetrating rate could be applied to the penetrating in the capillary of a tablet.
- 社団法人日本薬学会の論文
- 1963-11-25
著者
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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仲井 由宣
Faculty Of Pharmaceutical Science Chiba University
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福沢 寿
Faculty of Pharmacy, Chiba University
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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福沢 寿
Faculty Of Pharmaceutical Sciences Chiba University
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