Acceleration of the Addition Reaction of Succinic Anhydride and p-Nitroaniline in Controlled-Pore Glass Solid Dispersions

概要

論文の詳細を見る
The effects of controlled-pore glass (CPG) solid dispersion on the crystalline properties and solid-state reaction of succinic anhydride and p-nitroaniline have been investigated. From the powder X-ray diffraction and differential scanning calorimetry measurements, it was found that the mixing of organic compounds with CPG caused changes in their crystalline state. The addition reaction of succinic anhydride and p-nitroaniline in CPG mixtures was studied under various conditions. In the CPG mixtures, extreme acceleration of the addition reaction between succinic anhydride and p-nitroaniline was observed. The acceleration of the reaction can be explained in terms of the adsorption of organic molecules in the pores of CPG. In the cases of decreasing pore diameter and/or increasing CPG fraction, the reaction rate constants were significantly increased.
社団法人日本薬学会の論文
1989-11-25