Studies on Powdered Preparations. V. Studies on Particle Size Determination and Tablet Disintegration of Acetylsalicylic Acid by Thermal Analysis
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Theoretical considerations were made and fundamental experiments were carried out for thermal analysis by heat of solution. Acetylsalicylic acid -0.5M sodium citrate solution system was used and it was determined that thermal analysis was possible within a limit concentration of 0.6g./100cc. The particle-size distribution of acetylsalicylic acid powder was measured thermally and compared with microscopic method. Linear relationship was observed between particle diameter by microscopic method and solution time by thermal analysis. Disintegration processes of marketed tablets was elucidated by thermal analysis of heat of solution, same as the heat of reaction.
- 社団法人日本薬学会の論文
- 1960-07-25
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