Photoacoustic Spectroscopic Study of Cyclodextrin-Methyl Orange Systems

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Photoacoustic (PA) spectral measurements in the visible region were made for methyl orange contained in physical mixtures with α- and β-cyclodextrins, ground mixtures, and the inclusion compounds. Inclusion of methyl orange in β-cyclodextrin (molar ratio 1 : 1) was confirmed by the Bs type phase solubility diagram. The inclusion compounds of α- and β-cyclodextrins showed very similar PA patterns (λ_<max> at 445 nm) which were different from the pattern of the physical mixture (λ_<max> at 395 nm). The physical mixture showed a gradual change of its PA pattern of that of the inclusion type as a function of grinding time. The pattern of the ground mixture was broader than that of the inclusion compound, but became coincident with it after storage at 40℃ and 96% relative humidity for 4d.It was concluded that PA spectral measurement is an effective method to investigate inclusion phenomena in the solid state.
社団法人日本薬学会の論文
1988-11-25