パルビツール酸誘導体とポリエチレングリコールの複合体生成と分子間相互作用

概要

論文の詳細を見る
Complexes of several barbiturates and polyethylene glycol (PEG) are prepared by the coprecipitation method and the evaporation of equilibrated mixture from pyridine. Powder X-ray diffraction patterns and DSC curves indicate that phenobarbital, cyclobarbital, barbital, and pentobarbital form the complexes with PEG. It is also found that the grinding of barbiturates with PEG forms the complexes in a similar manner. From IR shifts of barbiturates in CCl_4 solution containing different amounts of tetraethylene glycol dimethyl ether, it is found that barbiturates are present in the molecular level in the solid complexes and that hydrogen bonding is formed between the N-H group of barbiturates and the oxygen atom of PEG. To investigate the effect of polymer chain length on the complex formation, the solubility phase diagram method and the viscosity measurement by Ostwald's viscometer are performed. It is assumed that one drug molecule interacts with two repeating units of -(CH_2-CH_2-O)-in PEG and for PEG at least four repeating units of -(CH_2-CH_2-O)- are needed to form the complexes.
社団法人日本薬学会の論文
1981-11-25