固形製剤中の塩酸ブロムヘキシンとポリエチレンフィルムとの相互作用(第1報)薬物の収着に及ぼす固形製剤中の水分量の影響

概要

論文の詳細を見る
The decrease of bromhexine HCl contents in granules and tablets was determined when the preparations were stored in polyethylene film package. Effects of temperature, contact area with film, excipients and moisture contents in the preparation on the remaining amount of bromhexin HCl were studied in order to investigate the interaction mechanism between bromhexine HCl and polyethylene film. It was observed that the decrease of bromhexine HCl was due to the sorption to the polyethylene film. The results indicated that the moisture contents of the dosage forms determined the rate of sorption predominantly, and that removal of adsorbed water from dosage forms was effective to prevent bromhexine HCl content decrease.
社団法人日本薬学会の論文
1989-12-25