固体医薬品及び添加剤の溶解度パラメターの測定

概要

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The solubility parameters of cefalexin, α-lactose monohydrate, controlled pore glasses with various pore diameters (75 to 1000Å) and silanized controlled pore glasses were determined by the gas-solid chromatographic method. As partial solubility parameters, dispersion term δ_d and other specific interaction term δ_d were used. The partial solubility parameters of δ_d and δ_s of α-lactose monohydrate were calculated to be 8.9 and 15.4 cal^<1/2>/cm^<3/2>, respectively and these values were in close agreement with those reported by Kesselring et al. On the controlled pore glasses, it was observed that the solubility parameters decreased from 106 to 76.6 cal^<1/2>/cm^<3/2> with an increase in diameter of controlled pore glass, and that this decrease resulted from the variations of δ_s values. To investigate the effects of surface hydrophilicity on solubility parameters of controlled pore glasses, silanol groups were inactivated by silanization. The solubility parameters could explain porous properties depending on the pore diameters of controlled pore glasses. The partial solubility parameters of δ_d and δ_s of cefalexin were determined to be 8.3,and 10.2 cal^<1/2>/cm^<3/2> for the crystal and 9.6,and 15.6 cal^<1/2>/cm^<3/2> for the amorphous, respectively. The solubility parameters were well correlated with the apparent saturated concentration of cefalexin.
公益社団法人日本薬学会の論文
1990-01-25