フローライト^<[○!R]>RE, アセトアミノフェン, ポリエチレングリコール混合粉砕物および錠剤からのアセトアミノフェンの溶解性

概要

論文の詳細を見る
Ground mixtures of Florite^<[◯!R]> RE (FR) (porous calcium silicate) and acetaminophen (ACTA) were prepared in order to improve the dissolution and compression characteristics of ACTA. No diffraction peaks due to ACTA crystals were observed in the powder X-ray diffraction pattern of the ground mixture with FR (FR : ACTA=9 : 1), which showed amorphization of ACTA crystals caused by grinding. The ground mixture produced an improved dissolution of ACTA in comparison with the ACTA crystals, and the tablets prepared from the ground mixture showed faster dissolution behaviour of ACTA than the tablets prepared from a physical mixture. Tablets of ternary ground mixture containing FR, ACTA and polyethylene glycol 6000 (PEG 6000) were prepared. The dissolution profile of ACTA from the tablet was found to be controlled by the PEG6000 content and compression pressure.
日本医療薬学会の論文
1995-02-10