医療現場における凍結乾燥注射剤の取り扱いの現状と課題

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The present situation of using injections prepared using the freeze-drying technique (FDI) was investigated by a questionnaire to nurses and pharmacists. From the results of the questionnaire, it appeared that their favorite formulas were FDIs prepared in glass vials because they are easy to handle and dissolve easily. The attached solvents to dissolve the FDI's were utilized by approximately 21% of the nurses. Adequate information about the solvents should be displayed on the body of the FDls vials and their attached documents. The intervals between the dissolution of FDIs and the administration to the patients, ranged from 30-60 min (36.7%). On the other hand, the attached documents recommended that they be "administered immediately following dissolution. This suggested that the significance decreased on the attached document did not reflect their use in practice. Though "the method of dissolving", 'the stability of medicine after dissolving", "the cure after dissolving" and "the stability of the FDIs's themselves" were cited as being frequent questions by the nurses, the descriptions about these items on the attached document were insufficient. The queries concerning FDIs to the pharmaceutical companies were mainly about the container and/or the FDIs, the changes in property of the FDIs, the admixture of foreign matter into the FDIs or the method of dissolution. The origin or the queries were due to both the accidents during the manufacturing process and the misuse of the FDIs by nurses. In order to, improve the rational use of injectable drugs, improved information provided by the attached document for FDIs is recommended.
日本医療薬学会の論文
2003-04-10

医療現場における凍結乾燥注射剤の取り扱いの現状と課題

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