患者に優しい製剤の開発 : ポリエチレンオキサイドおよびカラギーナン含有アロプリノール含嗽液の癌化学療法における口内炎予防効果

概要

論文の詳細を見る
The preventive effect of allopurinol mouthwash (Alkox-mw), which consists of allopurinol, polyethylene (oxide) (Alkox^[○!R]) and ι-carrageenan, regarding the problem of stomatitis induced by cancer chemotherapy and/or radiotherapy was investigated. The investigation was done on patients who were diagnosed with either esophageal or gastric cancer, and were treated by radiotherapy and/or chemotherapy using 5 -FU. The preventative effect of Alkox-mw was evaluated based on the common toxicity criteria advocated by the Japan Clinical Oncology Group. Alkox-mw was effective in 70% of the patients investigated in this study. Regarding cases of grade 1 stomatitis, the stomatitis healed after the regular use of the mouthwash treatment with Alkox-mw. However, even when Alkox-mw was used, the prognosis of the grade 2 or higher grade cases was not consistent. In a comparison of the preventative effect against stomatitis between Alkox-mw and mouthwash consisting of sodium carboxymethylcellulose (CMC-Na-mw), Alkox-mw was found to be more effective than CMC-Na-mw. The results obtained in this study thus suggest that Alkox-mw appears to be a useful preventative treatment modality against stomatitis.
日本医療薬学会の論文
2002-02-10