New Methods for Preparing Cyclodextrin Inclusion Compounds. I. Heating in a Sealed Container(Pharmaceutical,Chemical)

概要

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A new method for preparing a solid inclusion compound was developed. A physical mixture of benzoic acid and α- or β-cyclodextrin (CD) or the ground mixture was sealed in a container after adsorbing a definite amount of water vapor, then heated to a temperature ranging from 43 to 142℃. The results of powder X-ray diffraction and infrared 'spectroscopy showed that the crystalline inclusion compound was produced when the container was heated at over 70℃. The combining molar ratio of benzoic acid to α-CD in the inclusion compound prepared by this method was higher than that obtained by the coprecipitation method. Physical mixtures of benzoic acid and α or β-CD were also sealed in a stainless steel vessel under nitrogen gas pressure, then heated to 127℃. The pressurized samples had a higher combination ratio than the non-pressurized samples.
公益社団法人日本薬学会の論文
1987-11-25