錠剤内の粒子配列について(第2報)アスピリン結晶形状の粒子配列および成形性におよぼす影響

概要

論文の詳細を見る
An X-ray diffraction method for quantitative representation of the degree of orientation of aspirin crystals within a tablet was considered, and the effect of the shape of aspirin crystals on the degree of their orientation and the breaking strength of tablet was studied. Since, as reported previously, (100) faces of aspirin crystals aligned themselves parallel to the upper flat punch during compression, X-ray diffraction intensities, I, of (100) for the upper surface and faces parallel to it were strong, and those for oblique and normal faces were weak. Therefore, the degree of orientation was represented by the ratio of I of (100) for parallel face vs. that for normal face. As the shape of aspirin crystals became more flat, the degree of their orientation increased. Consequently, the tendency to laminate, that is, the ratio of breaking strength of a tablet in normal direction to upper surface vs. that in parallel direction, increased.
公益社団法人日本薬学会の論文
1978-02-25