Preferred Orientation of Crystallites in Tablets. II. Evaluation of Preferred Orientation of Crystallites by X-Ray Powder Diffractometry

概要

論文の詳細を見る
An X-ray powder diffraction method was presented to evaluate the preferred orientation of crystallites in tablets by using transmission and reflection techniques. In the present method, the X-ray diffraction intensities of the hkl reflections were measured with particular geometrical arrangements of the x-ray source, sample and detector so as to permit the measurement of diffraction intensities from the particular hkl planes oriented at various angles within the tablet. Thus, the preferred orientation plane was evaluated by comparing the observed intensities with the theoretical intensities calculated from the crystal structure factors.Aspirin, salicylic acid, benzoic acid and nicotinic acid were used as samples. In all samples, it was found that the crystallites had a preferred orientation in the tablet. The 100 plane in aspirin, the 110 or 210 plane in salicylic acid, the 002 plane in benzoic acid and the 002 plane in nicotinic aicd, had a tendency to orient parallel to the upper surface of the tablet during compression.
社団法人日本薬学会の論文
1991-12-25