Application of Eudragit RS to Thermo-Sensitive Drug Delivery Systems. I. Thermo-Sensitive Drug Release from Acetaminophen Matrix Tablets Consisting of Eudragit RS/PEG 400 Blend Polymers

概要

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In order to develop the polymer materials having temperature-sensitive and high biological safety, Eudragit RS-PO and polyethylene glycol 400 (PEG 400) blend polymers (EPG) were prepared. the EPGs that have the glass transition temperature (T_g) at around the body temperature were prepared by the addition of 5-13% PEG 400 to Eudragit RS. As glassy polymers are nto in themodynamic equilibrium below their T_g, the effects of isothermal aging on the T_gs of Eudragit RS and EPG containing 10% PEG 400(10% EPG) were also studied at various aging temperatures. The T_g values of Eudragit RS increased with the aging time and after 30d of aging, they apparently reached constant values which markedly differed denending on the aging temperatures. On the other hand, the T_g values of 10% EPG were almost independent of the aging temperature and reached around 33℃ at 30d after aging. The ability as thermo-sensitive polymer of EPG was evaluated by the dissolution test of the acctaminophen (AAP) matrix tablets prepared with EPG. The AAP release rate from the EPG matrix tablets slightly changed below the T_g of tablets, and then, it markedly increased above the T_g. Considering high biological safety of Eudragit RS and PEG 400,EPG might be available to develop the novel thermo-sensitive drug delivery systems.
公益社団法人日本薬学会の論文
2002-03-01