Use of Microcalorimetry in the Field of Pharmaceutical Sciences. I. Measurement of Drug Dissolution from Solid Dosage Forms
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概要
- 論文の詳細を見る
A microcalorimetric method for measurement of the dissolution rate of sodium chloride was presented. The method applied the deconvolution theory to heat conduction microcalorimetry. When a calorimetric curve for the heat of dilution was regarded as the response for a unit impulse input (heat conduction profile), a calorimetric curve for the heat of solution was considered to be the convolution of dissolution profile and heat conduction profile. Thus, the dissolution profile was calculated from the calorimetric curves for the heat of dilution and for the heat of solution by a numerical deconvolution. Dissolution rate determined by the calorimetric method coincided well with that obtained by a titration method.
- 社団法人日本薬学会の論文
- 1994-10-15
著者
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山村 重雄
東邦大学薬学部
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牧田 みどり
東邦大学薬学部
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吉橋 泰生
School Of Pharmaceutical Sciences Toho University
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福岡 英平
School of Pharmaceutical Sciences, Toho University
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牧田 みどり
School of Pharmaceutical Sciences, Toho University
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山村 重雄
School of Pharmaceutical Sciences, Toho University
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Yamamura S
School Of Pharmaceutical Sciences Toho University
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福岡 英平
School Of Pharmaceutical Sciences Toho University
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Makita M
School Of Pharmaceutical Sciences Toho University
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牧田 みどり
School Of Pharmaceutical Sciences Toho University
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MAKITA Midori
School of Pharmaceutical Sciences, Toho University
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山村 重雄
School Of Pharmaceutical Sciences Toho University
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Fukuoka E
Faculty Of Pharmaceutical Sciences Toho University
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Yamamura S
Toho Univ. Chiba Jpn
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