錠剤内の粒子配列について(第1報)配列状態の測定法

概要

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An X-ray diffraction method was developed for evaluating the preferred orientation of crystalline particles within a tablet. The selected faces of a tablet, the upper surface and faces cut parallel, oblique, and normal to the upper surface, were presented to the X-ray beam, and X-ray diffraction patterns for these faces were measured. From the difference in X-ray diffraction patterns for these faces of aspirin, phenacetin, ascorbic acid, DL-methionine, and talc tablets, the preferred orientation of crystals within a tablet was found to be induced during compression, and this result was also confirmed by the scanning electron microscopic observation. For example, in the case of an aspirin tablet, X-ray diffraction peak of (100) was observed for the upper surface and parallel face, while this peak was observed only a little for the normal face. This result showed that (100) faces of aspirin crystals aligned themselves parallel to the upper flat punch face during compression.
公益社団法人日本薬学会の論文
1978-01-25