Stability of Aspirin in Controlled Pore Glass Solid Dispersions
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概要
- 論文の詳細を見る
Effect of mixing with a controlled pore glass (CPG) on the stability of aspirin was studied under conditions of various relative humidities (RH), pore diameters of CPG and concentrations of aspirin. The crystallinity changes of aspirin in the mixtures with CPG170 or CPG3000 were also studied using the powder X-ray diffraction method and microscopy. The amorphous aspirin in the CPG mixtures showed an extremely fast decomposition rate, and a high rate was obtained when the pore diameter of the CPGs were less than 300 Å. In the mixtures of small pore diameter CPG, the decomposition rate constants were greater at a lower RH. These results can be explained in terms of the catalytic effect of free silanol groups on the surface of the CPG.
- 社団法人日本薬学会の論文
- 1991-04-25
著者
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米持 悦生
Faculty of Pharmaceutical Sciences, Chiba University
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小口 敏夫
Faculty of Pharmaceutical Sciences, Chiba University
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山本 恵司
Faculty of Pharmaceutical Sciences, Chiba University
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仲井 由宣
Faculty of Pharmaceutical Sciences, Chiba University
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仲井 由宣
千葉大学薬学部
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小口 敏夫
山梨大学医学部附属病院 薬剤部
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仲井 由宣
Tsumura And Co. Ibaraki Jpn
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仲井 由宣
Faculty Of Pharmaceutical Science Chiba University
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松村 学
Faculty of Pharmaceutical Sciences, Chiba University
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山本 恵司
Faculty Of Pharmaceutical Sciences Chiba University
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松村 学
Faculty Of Pharmaceutical Sciences Chiba University:(present Address)daiichi Pharmaceutical Co. Ltd.
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