製剤中の医薬品の分子状態について
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This paper reviews the researches on powdered preparations from the point of view of molecular pharmaceutics. Molecular behaviours of medicinals in the preparations are discussed in relating with physicochemical properties and bioavailability. Polymorphism, crystallinity including disorder parameter, and inclusion compounds are quoted as an example. Two methods that give the molecules high activity-grinding with microcrystalline cellulose or cyclodextrins and the mixing with porous powders-are explicated. The characteristic molecular behaviours in the mixtures are explained on the basis of X-ray diffraction, thermal, and infrared spectroscopic measurements.
- 公益社団法人日本薬学会の論文
- 1985-09-25
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関連論文
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- オクテット
- オクテット
- 製剤中の医薬品の分子状態について
- 混合粉砕に関する研究 : そのメカノケミカルな効果
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