Effects of Saccharide on the Decomposition of Cephalothin Sodium and Benzylpenicillin Potassium in Freeze-Dried Preparations

概要

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Freeze-dried samples of benzylpenicillin potassium or cephalothin sodium with a variety of saccharides were prepared. Effects of the saccharides on the stability of the antibiotics were investigarted in the binary freeze-dried samples. Addition of a saccharide accelerated the solid-state decomposition of antibiotics except for the case of cephalothin sodium-maltose and -lactose systems, and the decomposition rate was enhanced with an increase of the chain length of saccharide molecules. No significant difference in water content was found among the systems containing different kinds of saccharide. It was suggested that the stability of cephalothin sodium and benzylpenicillin potassium in the binary freeze-dried samples was affected by the molecular interactions with saccharide molecules.
社団法人日本薬学会の論文
1992-04-25