医薬品と多孔性粉体との相互作用(第2報)多孔性ガラス粉体との混合物からの安息香酸の昇華

概要

論文の詳細を見る
Sublimation of benzoic acid from a mixture of benzoic acid and porous glass powder (controlled pore glass, CPG) was examined. A large quantity of benzoic acid was retained in the mixture after heating in vacuo depending on heating temperature and mixing ratio. Especially for a low mixing ratio the mixture showed a high remaining percent. It is evident that capillaries of CPG played an important role in the benzoic acid retention since benzoic acid sublimated completely from a mixture of benzoic acid and fine glass beads having no capillaries. CPG-benzoic acid mixture of a low concentration mixture of CPG showed hallow pattern on powder X-ray diffractograms and no heat of melting on thermograms. Since benzoic acid molecules scarcely adsorbed in the aqueous solution, the adsorption of benzoic acid in the CPG-benzoic acid mixture is characteristic in the solidgas phase. The CPG-benzoic acid mixture showed a high dissolution rate of benzoic acid in aqueous solution, especially in initial dissolution stage. From the results described above it is concluded that benzoic acid molecules adsorbed tightly on the wall of capillaries in gas phase and easily released from the mixture in aqueous solution.
社団法人日本薬学会の論文
1985-03-25