Diffusion and Reaction of p-Nitroaniline and Succinic Anhydride in Controlled Pore Glass
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概要
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A multi-layered tablet which consisted of controlled pore glass (CPG) and organic compounds was prepared. Addition reactions between succinic anhydride and p-nitroaniline, which were induced separately in the CPG layers of the multi-layered tablet, have been studied. The reaction product, succinyl-p-nitroanilide, was mainly distributed near the p-nitroaniline layer. This can be explained in terms of a higher diffusion rate of succinic anhydride, resulting in its higher vapor pressure. The diffusion rate constant of succinic anhydride in the CPG120 system was evaluated as 6.00×10^<-7> cm^2/s by fitting the diffusion equation to experimental results.
- 社団法人日本薬学会の論文
- 1991-04-25
著者
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米持 悦生
Faculty of Pharmaceutical Sciences, Chiba University
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小口 敏夫
Faculty of Pharmaceutical Sciences, Chiba University
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山本 恵司
Faculty of Pharmaceutical Sciences, Chiba University
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仲井 由宣
Faculty of Pharmaceutical Sciences, Chiba University
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仲井 由宣
千葉大学薬学部
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小口 敏夫
山梨大学医学部附属病院 薬剤部
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仲井 由宣
Tsumura And Co. Ibaraki Jpn
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仲井 由宣
Faculty Of Pharmaceutical Science Chiba University
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山本 恵司
Faculty Of Pharmaceutical Sciences Chiba University
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