Preferred Orientation of Crystallites in Tablets. IV. Features of the Preferred Orientation Plane

概要

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Features of the preferred orientation plane of some organic crystals were studied from a quantum chemical point of view. The interaction energies in those crystal planes in which cleavage is possible were calculated by using the interaction energies between two molecules. The intermolecular interaction energies were calculated by the CNDO/2 (complete neglect of differential overlap) method. The preferred orientation planes, which have a tendency to orient themselves parallel to the upper surface of a tablet during compression, showed only small interaction energy. Thus, the preferred orientation of crystallites in a tablet was considered to occur by cleavage along that crystal plane which had small interaction energy during compression.
社団法人日本薬学会の論文
1993-07-15