アンジオテンシン変換酵素阻害薬の脂質・糖代謝への影響と臨床的有用性

概要

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In this paper we present the effects of angiotensin-converting enzyme (ACE) inhibitors on the total cholesterol (TC) and triglyceride (TG) levels in the serum, and the blood sugar (BS) levels in patients with slight to mild hyperlipidemia and diabetes. One hundred three outpatients treated with ACE, inhibitors were examined retrospectively. ACE inhibitors significantly decreased the TC, TG, and BS levels in hypertensive patients with slight hyperlipidemia or diabetes mellitus but who were not on medication. In hypertensive patients with mild hyperlipidemia treated with antilipemic agents, the ACE inhibitors did not decrease the TC and TG levels. In hypertensive patients with mild diabetes mellitus treated with antidiabetic agents, the ACE inhibitors also did not decrease the BS levels. These results show the decreasing effect of ACE inhibitors on the TC, TG and BS levels in patients with slight hyperlipidemia and diabetes mellitus in whom medication is not necessary. ACE inhibitors, therefore, have clinical usefulness of metabolizing the lipid and glucose in the serum, as well as acting as antihypertensive agents.
日本医療薬学会の論文
2003-12-10