Determination of Hydration kinetics of Sulfaguanidine Anhydrate in Aqueous Solution by Calorimetry

概要

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A heat conduction microcalorimeter was used to evaluate the isothermal transitionin water from anhydrate to monohydrate at 298 K. Sulfaguanidine (SGN) anhydrate was used as a model compound for the measurement of hydration kinetics in water. It is the well-known that SGN is very slighty soluble in water and capable of existing as the anhydrate or monohydrate form in the solid state. The transition rates of SGN anhydrate to monohydrate in tablets and granules were investigated. The hydration kinetics of tablets with controlled surface areas, obatined by coating the side with paraffin in aqueous solution, followed an apparent zero-order mechanism. Onthe other hand, the transision mechanism of the granules involved a phase boundary-controlled contracting interface reaction.
公益社団法人日本薬学会の論文
2000-02-01