Freeze-Drying of Proteins in Glass Solids Formed by Basic Amino Acids and Dicarboxylic Acids
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to produce and characterize glass-state amorphous solids containing amino acids and organic acids that protect co-lyophilized proteins. Thermal analysis of frozen solutions containing a basic amino acid (e.g., L-arginine, L-lysine, L-histidine) and a hydroxy di- or tricarboxylic acid (e.g., citric acid, L-tartaric acid, DL-malic acid) showed glass transition of maximally freeze-concentrated solute at temperatures (T'_g) significantly higher than those of the individual solute solutions. Mixing of the amino acid with some dicarboxylic acids (e.g., oxalic acid) also suggested an upward shift of the transition temperature. Contrarily, combinations of the amino acid with monocarboxylic acids (e.g., acetic acid) had T'_gs between those of the individual solute solutions. Co-lyophilization of the basic amino acids and citric acid or L-tartaric acid resulted in amorphous solids that have glass transition temperatures (T_g) higher than the individual components. Mid- and near-infrared analysis indicated altered environment around the functional groups of the consisting molecules. Some of the glass-state excipient combinations protected an enzyme (lactate dehydrogenase, LDH) from inactivation during freeze-drying. The glass-state excipient combinations formed by hydrogen-bonding and electrostatic interaction network would be potent alternative to stabilize therapeutic proteins in freeze-dried formulations.
- 公益社団法人日本薬学会の論文
- 2009-01-01
著者
-
Kawanishi Toru
National Institute Of Health Sciences
-
YONEMOCHI Etsuo
Faculty of Pharmaceutical Sciences, Chiba University
-
Yonemochi Etsuo
Faculty Of Pharmaceutical Sciences Toho University
-
Yonemochi Etsuo
School Of Pharmaceutical Sciences Toho Univ.
-
TERADA Katsuhide
Faculty of Pharmaceutical Sciences, Toho University
-
YOMOTA Chikako
National Institute of Health Sciences
-
Terada Katsuhide
Faculty Of Pharmaceutical Sciences Chiba University
-
Terada Katsuhide
Faculty Of Pharmaceutical Sciences Toho University
-
Terada Katsuhide
School Of Pharmaceutical Sciences Toho Univ.
-
IZUTSU Ken-ichi
National Institute of Health Sciences
-
KADOYA Saori
Faculty of Pharmaceutical Sciences, Toho University
-
Kadoya Saori
Faculty Of Pharmaceutical Sciences Toho University
関連論文
- Study of the Pseudo-Crystalline Transformation from Form I to Form II of Thiamine Hydrochloride (Vitamin B1)
- Specific Complexation of Ursodeoxycholic Acid with Guest Compounds Induced by Co-grinding. II. Effect of Grinding Temperature on the Mechanochemical Complexation
- Molecular States of 2-Naphthoic Acid in Solid Dispersions with Porous Crystalline Cellulose, as Investigated by Fluorescence Spectroscopy
- Formation of a Heptakis-(2,6-di-O-methyl)-β-cyclodextrin-p-nitrophenol Inclusion Compound by Sealed-Heating
- A Novel Analytical Method for Pharmaceutical Polymorphs by Terahertz Spectroscopy and the Optimization of Crystal Form at the Discovery Stage
- Development of Fast Disintegrating Compressed Tablets Using Amino Acid as Disintegratation Accelerator : Evaluation of Wetting and Disintegration of Tablet on the Basis of Surface Free Energy
- Hyaluronate Depolymerization Following Thermal Decomposition of Oxytetracycline
- Effect of Guest Species on Inclusion Compound Formation of Deoxycholic Acid by Co-Grinding
- IC/ICP-MSによるパン中臭素酸カリウムの特異的分析法
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. I. : Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs.
- Effect of Pore Size on the Gaseous Adsorption of Ethenzamide on Porous Crystalline Cellulose and the Physicochemical Stability of Ethenzamide after Storage
- Determination of Solubility Parameters for Solid Medicinals and Excipients
- STUDY OF FREEZE-DRYING IN DRUG-ADDITIVE BINARY SYSTEM
- POSSIBLE MECHANISM BEHIND THE INTERACTIONS BETWEEN POROUS POWDER AND CRYSTALLINE MEDICINALS
- Interaction of Microcrystalline Cellulose and Water in Granules Prepared by a High-Shear Mixer
- Feasibility of ^F-NMR for Assessing the Molecular Mobility of Flufenamic Acid in Solid Dispersions
- Participation of Cofilin in Opsonized Zymosan-Triggered Activation of Neutrophil-Like HL-60 Cells through Rapid Dephosphorylation and Translocation to Plasma Membranes^1
- Determination of Hydration kinetics of Sulfaguanidine Anhydrate in Aqueous Solution by Calorimetry
- Determination of Heat of Hydration and Hydration Kinetics of Theophylline by Thermal Analysis
- Measurement of Rates of Water Penetration into Tablets by Microcalorimetry
- Evaluation and Mechanism of Crystallite Orientation in Tablets
- Application of Eudragit RS to Thermo-Sensitive Drug Delivery Systems. I. Thermo-Sensitive Drug Release from Acetaminophen Matrix Tablets Consisting of Eudragit RS/PEG 400 Blend Polymers
- POLYMORPHISM OF TEGAFUR
- Quantification of Pharmaceutical Polymorphs and Prediction of Dissolution Rate Using Theophylline Tablet by Terahertz Spectroscopy
- LOSS OF VIABILITY AFTER DISULFIRAM TREATMENT WITHOUT PRECEDING DEPLETION OF INTRACELLULAR GSH
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. II. : Hepatotoxicity by the simultaneous administration of several drugs and nitrite.
- Characterization of Polymorphs of a Novel Quinolinone Derivative, TA-270(4-Hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone)
- Characteristics of Hyaluronate-hydroxyethyl Acrylate Blend Gel and Release of Cationic Amphiphilic Solutes
- Preparation and Characterization of Hyaluronate-Hydroxyethyl Acrylate Blend Hydrogel for Controlled Release Device
- Prediction of Measurement Precision by Chemometric Invalidation of Flow Pulsation in Refractive Index Detection of Liquid Chromatography
- Inhibition of Mannitol Crystallization in Frozen Solutions by Sodium Phosphates and Citrates
- Freeze-Drying of Proteins in Glass Solids Formed by Basic Amino Acids and Dicarboxylic Acids
- Stabilization of Protein Structure in Freeze-Dried Amorphous Organic Acid Buffer Salts
- Glass-State Amorphous Salt Solids Formed by Freeze-Drying of Amines and Hydroxy Carboxylic Acids : Effect of Hydrogen-Bonding and Electrostatic Interactions
- Protection of Protein Secondary Structure by Saccharides of Different Molecular Weights during Freeze-Drying
- Effect of Sodium Tetraborate (Borax) on the Thermal Properties of Frozen Aqueous Sugar and Polyol Solutions
- Improved Dissolution of Naproxen from Solid Dispersions with Porous Additives
- Influence of Particle Design on Oral Absorption of Poorly Water-Soluble Drug in a Silica Particle–Supercritical Fluid System
- Quantitative Determination of Amorphous Nicardipine Hydrochloride in Long Acting Formula (NIC-LA^[○!R]>) Using Light Anhydrous Silicic Acid
- BEHAVIOUR OF MEDICINAL MOLECULES IN THE INCLUSION COMPOUNDS OR GROUND MIXTURES WITH CYCLODEXTRINS
- PHYSICOCHEMICAL PROPERTIES OF TRI-O-METHYL-β-CYCLODEXTRIN AND ITS INTERACTIONS WITH DRUGS
- Complex Formation between Deoxycholic Acid and Menabione by Grinding and Sealed Heating Methods
- Preparation of Inclusion Complexes of 1-Adamantanol with Heptakis-(2, 6-di-O-methyl)-β-cyclodextrin by Sealed-Heating
- Application and Mechanism of Inhalation Profile Improvement of DPI Formulations by Mechanofusion with Magnesium Stearate
- Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC
- Comparison of Particle Size and Dispersion State among Commercial Cyclosporine Formulations and Their Effects on Pharmacokinetics in Rats
- Alterations in the Detergent-Induced Membrane Permeability and Solubilization of Saturated Phosphatidylcholine/Cholesterol Liposomes: Effects of Poly(ethylene glycol)-Conjugated Lipid
- Polyethylene Glycol Prevents in Vitro Aggregation of Slightly Negatively-Charged Liposomes Induced by Heparin in the Presence of Bivalent Ions
- Rapid and Sensitive Method for Measuring the Plasma Concentration of Doxorubicin and Its Metabolites
- Chemical Mapping of Hydration and Dehydration Process of Theophylline in Tablets Using Terahertz Pulsed Imaging
- Component Crystallization and Physical Collapse during Freeze-Drying of L-Arginine–Citric Acid Mixtures
- Do Amorphous Troglitazones Prepared from Two Diastereomer-Pairs Have the Same Molecular Mobility and Crystallization Rate at the Surface?
- Freeze-Drying of Proteins in Glass Solids Formed by Basic Amino Acids and Dicarboxylic Acids
- Using Terahertz Reflectance Spectroscopy to Quantify Drug Substance in Tablets
- Synthesis of VIP-Lipopeptide using a New Linker to Modify Liposomes: Towards the Development of a Drug Delivery System for Active Targeting
- Practical Approach for Measuring Heat Capacity of Pharmaceutical Crystals/Glasses by Modulated-Temperature Differential Scanning Calorimetry
- Thermotropic Phase Behavior of Hydrogenated Soybean Phosphatidylcholine–Cholesterol Binary Liposome Membrane
- Effects of Phosphate Buffer in Parenteral Drugs on Particle Formation from Glass Vials