Quantitative Determination of Amorphous Nicardipine Hydrochloride in Long Acting Formula (NIC-LA^[○!R]>) Using Light Anhydrous Silicic Acid
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概要
- 論文の詳細を見る
We investigated a method to quantitatively determine amorphous nicardipine hydrochloride (NIC) in the NIC-long acting formula (LA) model formulas prepared using NIC, light anhydrous silicic acid (LASA) and carboxymethylethylcellulose (CMEC). Consequently, since the quantity of total NIC in the formula can be determined by means of HPLC and crystal NIC can be determined by the differential scanning calorimetry (DSC) method because the heat of fusion (85.08 J/g) of NIC is constant and unaffected by excipients, we developed the HPLC-DSC method by which the quantity of amorphous NIC is calculated as the difference between the quantity of total NIC determined by HPLC and the quantity of crystal NIC determined by DSC. This practical HPLC-DSC method was confirmed to have good accuracy and reproducibility.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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Yonemochi Etsuo
School of Pharmaceutical Sciences, Toho University
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Terada Katsuhide
School of Pharmaceutical Sciences, Toho University
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Yonemochi Etsuo
School Of Pharmaceutical Sciences Toho Univ.
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Terada Katsuhide
School Of Pharmaceutical Sciences Toho Univ.
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KOHINATA Takeru
Pharmacovigirance Department, Yamanouchi Pharmaceutical Co., Ltd.
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FUJII Mitsuo
Patent Department, Yamanouchi Pharmaceutical Co., Ltd.
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NAKAMURA Souichiro
Novel Pharmaceutical Laboratory Yamanouchi Pharmaceutical Co., Ltd.
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HAMADA Noritaka
Analysis & Metabolism Laboratory, Yamanouchi Pharmaceutical Co., Ltd.
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Kohinata T
Pharmacovigirance Department Yamanouchi Pharmaceutical Co. Ltd.:school Of Pharmaceutical Sciences To
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Fujii Mitsuo
Patent Department Yamanouchi Pharmaceutical Co. Ltd.
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Hamada Noritaka
Analysis & Metabolism Laboratory Yamanouchi Pharmaceutical Co. Ltd.
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Nakamura Souichiro
Novel Pharmaceutical Laboratory Yamanouchi Pharmaceutical Co. Ltd.
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