Interaction of Microcrystalline Cellulose and Water in Granules Prepared by a High-Shear Mixer
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概要
- 論文の詳細を見る
Microcrystalline cellulose(MCC)granules were prepared by wet granulation using a high-shear mixer. Physical characteristics of the granules were investigated using near IR spectrometry, thermogravimetry and isothermal water vapor adsorption. Near IR spectra of dried MCC granules prepared for various granulation times exhibited different peak intensities at 1428, 1772, and 1920nm, which were assigned to functional groups of cellulose or water. On isothermogravimetric analysis, the rate of dehydration of water was shown to decrease with granulation time. These results suggest that the physical structure of MCC could change during the granulation process, and the interaction between MCC and water was gradually strengthened. The isothermal water vapor adsorption curves suggested that the amorphous region of MCC would be divided by the strong shear force of the impeller, because the high adsorption ability of intact MCC in the low humidity region was diminished in granules collected following 5 and 10 min of granulation. It was suggested that MCC formed a network which caught water within its structure during the wet granulation process.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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Yonemochi Etsuo
School of Pharmaceutical Sciences, Toho University
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Terada Katsuhide
School of Pharmaceutical Sciences, Toho University
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KIKUCHI Hiroshi
Drug Metabolism & Physicochemistry Research Laboratory, Tokyo R&D Center, Daiichi Pharmaceutical Co.
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YAMAMOTO Keiji
Faculty of Pharmaceutical Sciences, Chiba University
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Yonemochi Etsuo
School Of Pharmaceutical Sciences Toho University
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Suzuki T
Josai Univ. Saitama Jpn
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Yonemochi Etsuo
School Of Pharmaceutical Sciences Toho Univ.
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Terada Katsuhide
School Of Pharmaceutical Sciences Toho University
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Terada Katsuhide
School Of Pharmaceutical Sciences Toho Univ.
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Kikuchi H
Drug Metabolism And Physicochemical Property Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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SUZUKI Tatsuya
Pharmaceutical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd.
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Yamamoto Keiji
Faculty Of Pharmaceutical Sciences Chiba University
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Yamamoto Keiji
Faculty Of Materials Science And Engineering Science University Of Tokyo In Yamaguchi
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Suzuki Tatsuya
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science:Laboratory of Microbiology, Hatano Research Institute, Food and Drug Safety Center
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