Preparation and Biological Activities of Sulfated Derivatives of (1→3)-β-D-Glucans
スポンサーリンク
概要
- 論文の詳細を見る
Sulfated derivatives of (1→3)-β-D-glucans with different degree of branching (DB) i.e., curdlan (linear, DB 0), grifolan (6-O-substituted by β-D-glucose at every third residue of the main chain, DB 1/3), and SSG (6-O-substituted by β-D-glucose at every second residue, DB 1/2) having DS value (degree of substitution) lower than 0.6 were prepared. Biological activities [clotting of plasma, alternative pathway of complement (APC), proliferative response of murine spleen cells (mitogenic activity), and activation of murine peritoneal macrophages in vitro] of these derivatives were examined. Clotting of plasma was inhibited by the derivatives having DS above 0.2. APC was inhibited by incubation with derivatives and was strongly dependent on substitution. Inhibition of APC was the most significant in sulfated SSG having DS 0.6 [SSG (3)]. Mitogenic activity was observed by most of the derivatives and the highest activity was shown by SSG (1) (DS 0.2). Macrophage was also activated but SSG (1) would lose the capability to recognize the receptor for (1→3)-β-D-glucans. From these results, it appears that the biological activities of (1→3)-β-D-glucans were significantly modulated by sulfation and the effect was dependent on both DS and DB.
著者
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OHNO NAOHITO
Tokyo College of Pharmacy
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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ADACHI Yoshiyuki
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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YADOMAE Toshiro
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Suzuki T
Josai Univ. Saitama Jpn
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SUZUKI Tatsuya
Tokyo College of Pharmacy
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CIRELLI Alicia
Tokyo College of Pharmacy
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COVIAN Javiar
Tokyo College of Pharmacy
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Yadomae Toshiro
Tokyo College Of Pharmacy
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Covian Javiar
Tokyo College Of Pharmacy:universidad De Buenos Aires Pabellon Ii Ciudad Universitaria
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Cirelli Alicia
Tokyo College Of Pharmacy:universidad De Buenos Aires Pabellon Ii Ciudad Universitaria
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Suzuki Tatsuya
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science:Laboratory of Microbiology, Hatano Research Institute, Food and Drug Safety Center
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