ANTITUMOR ACTIVITY OF A HIGHLY BRANCHED (1→3)-β-D-GLUCAN, SSG, OBTAINED FROM SCLEROTINIA SCLEROTIORUM IFO 9395
スポンサーリンク
概要
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The antitumor activity of a highly branched (1→3)-β-D-glucan, SSG, purified from the liquid culture filtrate of Sclerotinia sclerotiorum IFO 9395 and its several derivatives were treated in ICR mice bearing Sarcoma 180 cells. SSG was effective by both systemic (intraperitoneal and intravenous) and local (intratumoral) administrations on the solid form of Satcoma 180 in ICR mice and the mice acquired resistance to subsequent inoculation of Sarcoma 180. However, SSG was not effective on the ascites form Sarcoma 180. The pretreatment of ICR mice with carrageenan suppressed the antitumor activity, suggesting the involvement of macrophages on the antitumor activity. Derivatives prepared from SSG by periodate oxidation/borohydride reduction showed antitumor activity, but those obtained after acetylation, carboxymethylation and hydroxyethylation were less active. From these results, it is suggested that SSG is a useful antitumor glucan which modifies biological responses and can be used as a source for some antitumor derivatives.
- 公益社団法人日本薬学会の論文
著者
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OHNO NAOHITO
Tokyo College of Pharmacy
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YADOMAE Toshiro
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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KURACHI KAZUYA
Tokyo College of Pharmacy
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Kurachi K
Lab. Immunopharmacolgy Of Microbial Products Tokyo University Of Pharmacy And Life Science School Of
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Yadomae Toshiro
Tokyo College Of Pharmacy
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