The Effects of a Highly Branched β-1,3-Glucan, SSG, Obtained from Sclerotinia sclerotiorum IFO 9395 on the Growth of Syngeneic Tumors in Mice
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概要
- 論文の詳細を見る
The effects of a highly branched β-1,3-glucan, SSG, obtained from a culture filtrate of a fungus, Sclerotinia sclerotiorum IFO 9395,on the growth of syngeneic tumors and antitumor effector cells were examined. In the Meth A solid tumor systems, SSG administered intraperitoneally (i.p.), intralesionally (i.l.), or intravenously (i.v.) showed significant antitumor activities. Furthermore, SSG administered i.p. also showed effective activities against IMC carcinoma. SSG enhanced nonspecific antitumor effector functions, such as natural killer activity of spleen cells and the cytolytic activity of peritoneal macrophages. Additionally, SSG increased the specific immune response (cytotoxic T lymphocyte activity) against allogeneic tumor cells.
- 公益社団法人日本薬学会の論文
著者
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SUZUKI IWAO
Tokyo College of Pharmacy
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Hashimoto Koichi
Research Institute For Sustainable Humanosphere Kyoto University
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Suzuki Iwao
Faculty Of Pharmaceutical Sciences Tohoku University
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Yadomae Toshiro
Tokyo College Of Pharmacy
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HASHIMOTO Koichi
Tokyo College of Pharmacy
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