EFFECT OF A B CELL MITOGEN EXTRACTED FROM A FUNGUS PEZIZA VESICULOSA ON ANTIBODY PRODUCTION IN MICE

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概要

• 論文の詳細を見る

• The effect of Vesiculogen (a hot-water extracted B cell mitogen from Peziza vesiculosa) on antibody production in mouse spleens was studied. The number of plaqueforming cells (PFC) elicited by injection with Vesiculogen and/or 2,4,6-trinitrophenyl substituted sheep red blood cells (TNP-SRBC) were comparatively assayed. In the mice injected with 100 μg of Vesiculogen (i. p.), an obvious increase in the numbers of anti-SRBC and anti-TNP SRBC PEC in spleens was observed after 2 d of injection, and the numbers of PFC reached a maximum on day 3. Injections to 1-1000 μg of Vesiculogen were effective. This effect was shown when Vesiculogen was administered by i. p. or i. v. injections. In some cases, the numbers of PFC in mice injected with Vesiculogen and antigen exceeded the sum of each number of PFC elicited by polycolonal B cell activation activity of Vesiculogen and by antigenic stimulation of TNP-SRBC. Pretreatment with Vesiculogen within 4 d before immunization markedly reduced the PFC response. These results suggest that the effect of Vesiculogen on antibody response in mice attributes to its activities as a polyclonal B cell activator and adjuvant.

• 社団法人日本薬学会の論文

著者

• OHNO NAOHITO

  Tokyo College of Pharmacy

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• YADOMAE Toshiro

  Tokyo University of Pharmacy and Life Science, School of Pharmacy

• SUZUKI IWAO

  Tokyo College of Pharmacy

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• YONEKUBO HISAO

  Tokyo College of Pharmacy

• MIYAZAKI TOSHIO

  Tokyo College of Pharmacy

• Miyazaki T

  Department Of Applied Microbiology Nippon Roche Research Center

• Suzuki Iwao

  Faculty Of Pharmaceutical Sciences Tohoku University

• Yadomae T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Yadomae Toshiro

  Tokyo College Of Pharmacy

• Yonekubo H

  Tokyo College Of Pharmacy

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