Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β-Glucan in Mice

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概要

• 論文の詳細を見る

• The distribution of a ^3H-labeled chemically modified antitumor β-glucan, grifolan NMF-5N (I/B), in various tissues after an injection into mice was examined in order to obtain information on distribution of the parent antitumor β-glucan, grifolan NMF-5N. Grifolan NMF-5N was treated with sodium metaperiodate and sodium borotritide to obtain tritium-labeled grifolan NMF-5N [^3H-grifolan (I/B)]. When ^3H-grifolan (I/B) was administered into normal mice by intraperitoneal (i.p.) or intravenous (i.v.) injection, radioactivity was detected in various mouse tissues. Next, ^3H-grifolan (I/B) was injected into tumor-bearing mice 7 d after the tumor inoculation, which is the most effective administration timing for the antitumor effect of grifolan NMF-5N. The results indicated a strong radioactivity in spleens and tumor masses. These results suggested a close relationship between the antitumor activity and the distribution of grifolan NMF-5N in mice.

• 社団法人日本薬学会の論文

著者

• OHNO NAOHITO

  Tokyo College of Pharmacy

• Ohno Naohito

  東京薬科大学 免疫学

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• Ohno N

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• YADOMAE Toshiro

  Tokyo University of Pharmacy and Life Science, School of Pharmacy

• SUZUKI IWAO

  Tokyo College of Pharmacy

• OIKAWA Shozo

  Tokyo College of Pharmacy

• Ohno Naohito

  Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• OHSAWA Masumi

  Tokyo College of Pharmacy

• TAKEYAMA Takahiro

  Tokyo College of Pharmacy

• SATO Kichiro

  Tokyo College of Pharmacy

• Oikawa S

  Nippon Beet Sugar Mfg. Co. Ltd. Tokyo Jpn

• Sato K

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Ohsawa M

  Nippon Beet Sugar Mfg. Co. Ltd. Tokyo Jpn

• Suzuki Iwao

  Faculty Of Pharmaceutical Sciences Tohoku University

• Yadomae T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Yadomae Toshiro

  Tokyo College Of Pharmacy

• Takeyama Takahiro

  Tokyo College Of Pharmacy:nippon Beet Sugar Mfg. Co. Ltd.

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